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Terms Of Use


Brand Name(s) : Stelazine
Side Effects


Trifluoperazine should be used with caution in:

It should not be used in:

  • People in a coma (decreased consciousness)
  • People with blood disorders
  • People with liver damage
  • People with allergies to trifluoroperazine, or other phenothiazine tranquillisers or any of the other ingredients.

Also see list of precautions and interactions


Trifluoperazine should be stored below 25°C and protected from light.


What is it used for?

  • Trifluoperazine is used to decrease the effect of a natural chemical in the brain called dopamine.
  • It is a phenothiazine tranquilliser, sometimes known as narcoleptic.
  • It is used to reduce the over activity of the brain cells.
  • In general this drug is used manage anxiety, feeling sick (nausea) and being sick (vomiting) at low doses and schizophrenia (split personality), paranoia, agitation and behavioural problems when given as a high dose.

Listed below are the typical uses of trifluoperazine.

  • At a low dosage: it is used to manage anxiety, depression caused by anxiety and agitation; nausea (feeling sick) and vomiting (being sick).
  • At high doses: schizophrenia and related conditions, severe agitation or dangerous behaviour.


How often do I take it?

  • Take this medication orally as directed by your doctor.
  • Use this medication for as long as your doctor tells you to take it in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take several weeks before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • This medicine may cause drowsiness, dizziness and blurred vision. Take care if you are driving, operating machinery or doing other activities where you need to be alert. You should not do any of these activities if you experience any of these effects; if you suffer badly tell your doctor. Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.
  • If you stop your treatment suddenly, your symptoms may come back. It is advisable to gradually reduce the dose. If you suddenly stop taking this medicine, you are more likely to experience symptoms, such as nausea, vomiting, sweating and insomnia. You may also experience involuntary muscle disorders, anxiety, inability to sit quietly and irregular contortions of the muscles.


  • Tiredness
  • Drowsiness
  • Dizziness
  • Restlessness
  • Inability to sleep
  • Dry mouth
  • Muscle weakness
  • Blurred vision
  • Anorexia (i.e. loss of appetite)
  • Dizziness when standing up
  • Skin reactions including unusual sensitivity to light
  • Weight gain
  • Water retention
  • Confusion.
If any of these persist or you consider them severe then inform your doctor.

Tell your doctor immediately if you develop any of the following symptoms:

  • Slurred speech
  • Odd movements of the face particularly of the tongue, eyes, head or neck (such as twisting of the neck which causes an unnatural positioning of the head)
  • Rigid muscles
  • Tremors or restlessness
  • Difficulty in keeping still
  • Constant chewing or tongue movements
  • Other gentle movements of the head, neck or trunk
  • Uncontrollable movements of the arms and legs
  • A group of symptoms including high temperature, muscle stiffness, drowsiness and altered consciousness
  • Worsening angina pain
  • Severe sore throat
  • High fever
  • Very tired and pale
  • Bruises
  • Nose bleeds

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.


Before taking trifluoperazine, tell your doctor or pharmacist if you are allergic to it; or to other phenothiazine tranquillisers; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

  • A blood disorder
  • Liver damage
  • Allergies to trifluoroperazine, or other phenothiazine tranquillisers or any of the other ingredients.

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following:

  • If you are elderly
  • If you have heart problems, or a family history of heart problems, including abnormal heart rhythms and angina
  • If you have Parkinson’s disease
  • If you have epilepsy
  • if you have narrow angle glaucoma
  • If you have myasthenia gravis, a disease characterised by chronic fatigue and muscular weakness (especially in the face and neck)
  • If you have an enlarged prostate
  • If you are pregnant
  • If you are breast feeding.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • You must not drink alcohol while taking trifluoperazine.

The elderly: if you are elderly you should take trifluoperazine with caution.

Pregnancy and breastfeeding - please ensure you read the detailed information below


The safety of trifluoperazine has not been established during pregnancy. Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Trifluoperazine is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Before using this medicine, tell your prescriber of all the medicines you are taking including prescription medicines and medicines you have bought over the counter without a prescription. Tell your prescriber if you are taking vitamins or complementary remedies such as herbal products, as these can also interact with medicines.

If you are taking more than one medicine, these may interact with each other. Your prescriber may decide to use medicines which interact with each other if the benefit outweighs the risks. In these cases, the dose of your medicines may need to be adjusted or you may be monitored more closely.

The following medicines may interact with trifluoperazine:

  • Desferrioxamine
  • Sleeping tablets
  • Strong painkillers
  • Guanethidine
  • Levodopa
  • Metrizamide
  • Anti-convulsants (taken to prevent fits)
  • Anti-cholinergic medicines (e.g. atropine, procyclidine) which may have been used for bladder, bowel or chest problems
  • Anti-depressants
  • Medicines which reduce white blood cell production
  • Antacids
  • Medicines to thin your blood (anticoagulants).

This information does not contain all possible interactions. Therefore, tell your prescriber of all the products you are using before taking this medicine.

If you have a question or want to discuss anything about your medicine, speak to your local pharmacist.


If you think you, or someone you care for, might have accidentally taken more than the recommended dose of trifluoperazine or intentional overdose is suspected, immediately contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.


If you miss a dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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