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Terms Of Use


Brand Name(s) : Aquadrate, Eucerin Intensive, Nutraplus, Balneum, Calmurid, Dermatonics Heel Balm, E45 Itch Relief Cream, Flexitol, Hydromol Intensive
Side Effects


Urea should be used with caution in:

  • None known

It should not be used in:

  • Allergy (hypersensitivity) to urea or any of the other ingredients
  • Broken or moist skin

Also see list of precautions and interactions


Store below 30°C.


What is it used for?

  • Urea is used to treat chronic dry skin conditions, such as eczema. It is also used to treat skin conditions that cause dry, thickened, scaly, flaky and cracked skin (ichthyosis, xeroderma) and thickening of the outermost layer of the skin (hyperkeratosis).
  • It is an emollient, also known as a moisturiser.
  • It is used to relieve the symptoms of dry skin conditions, such as cracked, scaly and itchy skin. The urea penetrates the skin's surface where it absorbs water. This results in a soothing, softening and moisturising effect.
  • In general preparations containing urea are used for long-term dry skin conditions.

Benefits of using urea can include: making the skin softer and preventing thick, dry skin.

Listed below are the typical uses of urea:

  • For the relief of symptoms of chronic skin conditions, such as dry, scaling and itching skin

On occasion your doctor may prescribe this medicine to treat a condition not on the above list. Such conditions are listed below.

  • None known


How often do I take it?

  • Use urea preparations exactly as your doctor has told you.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.

What dose?

  • Dosage is based on your medical condition.

Do I need to avoid anything?

  • Avoid applying the cream to broken, moist or weeping skin. Avoid getting the cream in your eyes. Consult your doctor or pharmacist for more details.

When can I stop?

  • Always complete the full course as prescribed by your doctor.


  • Redness, itching or burning sensations where applied
  • Swelling when applied to sensitive, moist or broken skin
If any of these persist or you consider them severe then inform your doctor or pharmacist.

Tell your doctor immediately if you develop any of the following symptoms:

  • None known

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.


Before using urea preparations, tell your doctor or pharmacist if you are allergic to it; or to other emollients; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

  • Allergy (hypersensitivity) to urea or any of the other ingredients
  • Broken or moist skin

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following:

  • None known

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol does not affect this drug.

Pregnancy and breastfeeding - please ensure you read the detailed information below


Urea is suitable to use during pregnancy. Ask your doctor or pharmacist if you have any doubts or questions about this.

It is sensible to limit use of medication during pregnancy whenever possible.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Urea is suitable to use if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Before using this medicine, tell your prescriber of all the medicines you are taking including prescription medicines and medicines you have bought over the counter without a prescription. Tell your prescriber if you are taking vitamins or complementary remedies such as herbal products, as these can also interact with medicines.

There are no known significant interactions between urea and other medicines. If you experience any unusual symptoms while using this medicine with other medicines, tell your prescriber.

If you have a question or want to discuss anything about your medicine, speak to your local pharmacist.


Application of excessive amounts of urea cream may cause skin irritation, but no other effects would be expected. If this occurs, wash the cream off and stop using it.

If you swallow a large amount of urea cream, you may feel or be sick. If this happens, contact your doctor or nearest hospital casualty department as soon as possible.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of urea or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.


If you miss an application of the cream, take it as soon as you remember. If it is near the time of your next application, skip the missed application and resume your usual schedule. Do not use more cream to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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