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Brand Name(s) : Clopixol
Side Effects


Zuclopenthixol dihydrochloride should be used with caution in:

It should not be used in:

  • People with hypersensitivity to the active substance or to any of the other ingredients
  • People with circulatory collapse
  • People with a depressed level of consciousness due to any cause (e.g. intoxication with alcohol, barbiturates or opiates)
  • Also see list of precautions and interactions


    Keep the tablets in their original container, protected from light and moisture. Store below 25°C.


What is it used for?

  • Zuclopenthixol dihydrochloride is used to correct certain chemical imbalances in the brain.
  • It is a neuroleptic, sometimes known as an antipsychotic.
  • It is a sedative used to treat schizophrenia and related conditions.

Listed below are the typical uses of zuclopenthixol dihydrochloride:


How often do I take it?

  • Take this medication orally, in accordance with your doctor's instruction, with a glass of water, usually twice a day.
  • Use this medication regularly in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • It may take up to 6 hours before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • Zuclopenthixol hydrochloride is a sedative drug.
  • Alertness may be impaired, especially at the start of treatment, or following the consumption of alcohol; patients should be warned of this risk and advised not to drive or operate machinery until their susceptibility is known.
  • Patients should not drive if they have blurred vision.
  • Consult your doctor or pharmacist for more details.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.


If any of these persist or you consider them severe then inform your doctor.

Tell your doctor immediately if you develop any of the following symptoms:

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.


Before taking zuclopenthixol dihydrochloride, tell your doctor or pharmacist if you are allergic to it; or to other neuroleptics; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

  • Hypersensitivity to the active substance or to any of the other ingredients,
  • Circulatory collapse,
  • Depressed level of consciousness due to any cause (e.g. intoxication with alcohol, barbiturates or opiates), coma.

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following:

  • previous history of severe side effects with, or allergy to, other neuroleptic medicines,
  • liver disease
  • heart condition
  • family history of heart problems
  • irregular heart beat
  • risk factors for stroke e.g. smoking, high blood pressure
  • severe respiratory disease
  • renal failure
  • epilepsy
  • conditions predisposing to epilepsy e.g. alcohol withdrawal or brain damage
  • Parkinson's disease
  • narrow angle glaucoma
  • enlarged prostate
  • hypothyroidism
  • hyperthyroidism
  • myasthenia gravis (a condition causing severe muscle weakness)
  • phaeochromocytoma (a type of cancer of the adrenal gland)
  • the elderly

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • If you drink alcohol you may find it affects you more than usual. Consult your doctor or nurse for advice.

The elderly: zuclopenthixol dihydrochloride should be used with caution in the elderly as they are more prone to developing side effects.

Pregnancy and breastfeeding - please ensure you read the detailed information below


Zuclopenthixol dihydrochloride is not safe to take if you are, or are planning to become, pregnant.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Zuclopenthixol dihydrochloride is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Before using this medicine, tell your prescriber of all the medicines you are taking including prescription medicines and medicines you have bought over the counter without a prescription. Tell your prescriber if you are taking vitamins or complementary remedies such as herbal products, as these can also interact with medicines.

If you are taking more than one medicine, these may interact with each other. Your prescriber may decide to use medicines which interact with each other if the benefit outweighs the risks. In these cases, the dose of your medicines may need to be adjusted or you may be monitored more closely.

The following medicines may interact with zuclopenthixol dihydrochloride:

  • Barbiturates
  • CNS depressants
  • General anaesthetics
  • Anticoagulants
  • Anticholinergics
  • Atropine
  • Metoclopramide
  • Piperazine
  • Antiparkinson drugs
  • Lithium
  • Sibutramine
  • Quinidine
  • Corticosteroids
  • Digoxin
  • Hydralazine
  • Doxazosin
  • Methyldopa
  • Quinidine
  • Amiodarone
  • Sotalol
  • Dofetilide
  • Anti-psychotics such as thioridazine
  • Macrolide antibiotics such as erythromycin
  • Antihistamines
  • Quinolone antibiotics such as moxifloxacin
  • Cisapride
  • Lithium
  • Thiazide diuretics
  • Levodopa or other medicines used to treat Parkinson’s disease

This information does not contain all possible interactions. Therefore, tell your prescriber of all the products you are using before taking this medicine.

If you have a question or want to discuss anything about your medicine, speak to your local pharmacist.


If you accidentally take too much zuclopenthixol dihydrochloride you should contact a doctor or hospital immediately. If you go to the doctor/hospital take the zuclopenthixol dihydrochloride bottle with you. The doctor may need to give you supportive treatment (e.g. other medicine) for any symptoms that result from the overdose. These symptoms could include sedation, coma, shock, fainting, tremors, fits or temperature changes.

People who have taken too much zuclopenthixol dihydrochloride should seek medical advice.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of megestrol or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.


If you miss a dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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