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Terms Of Use

BEZAFIBRATE

Brand Name(s) : Bezalip, Bezalip Mono, Fibrazate (Bezatard) XL, Zimbacol XL
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

BEZAFIBRATE WARNINGS

Bezafibrate should be used with caution in people with any of the following which may increase the risk of developing muscle disease: patients who have an impaired kidney function or who regularly drink alcohol to excess, those with an underactive thyroid (hypothyroidism), trauma, severe infection, hormone or blood chemical disturbances or patients awaiting surgery.

It should not be used in people: allergic to bezafibrate or to any other ingredient in the tablets, allergic to fibrates or have developed sensitivity to sunlight or artificial light whilst taking these medicines, undergoing kidney dialysis, with a kidney disorder called nephrotic syndrome or with low blood levels of a protein called albumin (hypoalbuminaemia), with serious liver problems, gallbladder disease, or in those using statin medicines where they are also at increased risk of developing muscle weakness and pain (myopathy) or severe muscle damage (rhabdomyolysis) such as those with poor kidney function, hypothyroidism, severe infection, trauma, surgery, hormone or blood chemical disturbances, or a high alcohol intake

Also see list of precautions and interactions.

STORAGE

No special storage conditions are required.

BEZAFIBRATE USES

What is it used for?

  • Bezafibrate is used to treat a number of problems.
  • It is a member of a class of lipid-modifying drugs, sometimes known as fibrates.
  • It is used to lower levels of cholesterol and other lipids (fats) in the blood.
  • In general this drug is used to reduce high (harmful) levels of lipids such as triglycerides in the blood, but is also used to reduce high levels of other blood lipids such as low-density lipoprotein cholesterol (LDL-C), or to increase levels of a type of cholesterol that protects against heart disease and stroke (high-density lipoprotein cholesterol, or HDL-C).
  • Benefits of being on this drug include reducing the likelihood of cardiovascular disease events (e.g. heart attacks or stroke) and prolonged life.

Listed below are the typical uses of bezafibrate.

  • Treating a range of abnormal blood triglyceride/cholesterol levels (e.g. hypertriglyceridaemia, hypercholesterolaemia or mixed dyslipidaemia) when other measures such as diet, weight reduction and exercise, have failed to control these abnormalities.

On occasion your doctor may prescribe this medicine to treat a condition not on the above list.

HOW TO USE/TAKE

How often do I take it?

  • Take this medication orally, usually three times a day after food. Tablets should be taken whole with water.
  • Modified release tablets are usually taken once daily. These should be taken whole and must not be chewed or crushed.
  • Use this medication regularly in order to get the most benefit from it.
  • Bezafibrate and anion exchange resin drugs (e.g. colestyramine) should not be taken within 2 hours of each other.
  • Remember to use it at the same time each day – unless specifically told otherwise by your doctor.
  • It may take some time before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • Bezafibrate may cause dizziness and can have a minor to moderate effect on the ability to drive or use machines, so patients should not drive or use machines if they are affected.

When can I stop?

  • It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.

BEZAFIBRATE SIDE EFFECTS

Only the most common side effects have been listed. If any of these persist or you consider them severe then inform your doctor.

Tell your doctor immediately if you develop any of the following symptoms: muscle aches and pains, tenderness, weakness or cramps, particularly if you also feel generally unwell and/or have a fever; symptoms indicating liver problems and/or the formation of gallstones (pain in the upper belly or yellowing of the skin or eyes [jaundice]).

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

BEZAFIBRATE PRECAUTIONS

Before taking bezafibrate, tell your doctor or pharmacist if you are allergic to it; or to other fibrate; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: a severe infection, any liver or kidney problems, are undergoing kidney dialysis, have gallbladder disease, have an underactive thyroid (hypothyroidism), if you drink substantial quantities of alcohol, or if you have muscle pains, cramps or muscle tenderness or weakness.

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following: Photosensitivity to fibrates, any previous liver problems, any previous unexplained muscle pains, cramps or muscle tenderness or weakness, recent injury or surgery, recent changes in the levels of hormones or chemicals in the blood, or whether you or you have a close family member who has had a hereditary (genetic) muscle disorder or muscle problems with statins or other lipid-modifying drugs.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Yes. Avoid drinking large quantities of alcohol whilst taking bezafibrate.

Pregnancy and breast-feeding - please ensure you read the detailed information below.

PREGNANCY

The safety of bezafibrate has not been established during pregnancy. Speak to your doctor before taking this medicine during pregnancy or if you are planning to become, pregnant.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

It is not known whether bezafibrate passes into breast milk. The manufacturer therefore states that it should not be taken if you are breastfeeding..

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BEZAFIBRATE INTERACTIONS

Before using this medicine, tell your prescriber of all the medicines you are taking including prescription medicines and medicines you have bought over the counter without a prescription. Tell your prescriber if you are taking vitamins or complementary remedies such as herbal products, as these can also interact with medicines.

If you are taking more than one medicine, these may interact with each other. Your prescriber may decide to use medicines which interact with each other if the benefit outweighs the risks. In these cases, the dose of your medicines may need to be adjusted or you may be monitored more closely.

The following medicines may interact with bezafibrate:

  • Anion-exchange resins such as colestipol or colestyramine
  • Statins such as atorvastatin, simvastatin, pravastatin, fluvastatin or rosuvastatin
  • Ezetimibe
  • Daptomycin an antibiotic
  • Antidiabetic medicines such as insulin or sulphonylureas
  • Monoamine oxidase inhibitors such as phenelzine
  • Blood-thinning agents such as warfarin, acenocoumarol or phenindione
  • Ciclosporin an immunosuppressant
  • Oestrogen or medicines containing oestrogen

This information does not contain all possible interactions. Therefore, tell your prescriber of all the products you are using before taking this medicine.

If you have a question or want to discuss anything about your medicine, speak to your local pharmacist.

BEZAFIBRATE OVERDOSE

No specific effects of acute overdose are known (apart from severe muscle damage, known as rhabdomyolysis).

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of bezafibrate or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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