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Terms Of Use

BRINZOLAMIDE

Brand Name(s) : Azopt
Warnings
Uses
Side Effects
Precautions
Interactions
Overdose

BRINZOLAMIDE WARNINGS

Brinzolamide should be used with caution in:

It should not be used in:

  • People with allergies to brinzolamide or any of the other ingredients in the medicine.
  • People allergic to medicines called sulfonamides (antibacterials)
  • People who have severe kidney problems
  • People with a condition called hypercholoraemic acidosis that causes blood to be acidic
  • Children under the age of 18 years (unless advised by your doctor)

Also see list of precautions and interactions

STORAGE

Brinzolamide does not require any special storage conditions. Discord bottle four weeks from opening.

BRINZOLAMIDE USES

What is it used for?

  • Brinzolamide is used to treat raised pressure inside the eye due to open-angle glaucoma or ocular hypertension. It can be used on its own in people who cannot take beta-blockers or in whom beta-blockers do not work, or in addition to beta-blockers or prostaglandin analogues when one drug is not enough to lower the pressure.
  • It is a type of carbonic anhydrase inhibitor.
  • It is used to inhibit an enzyme called carbonic anhydrase, which is responsible for the production and breakdown of carbonic acid. This process produces bicarbonate, which is needed for the watery fluid in the eye (aqueous humour). The pressure in the eye is reduced by stopping the enzyme from working, thereby reducing the amount of fluid in the eye.
  • In general this drug is used to reduce elevated pressure inside the eye due to open-angle glaucoma and ocular hypertension.
  • Benefits of being on this drug can include:
    Reduction of raised pressure inside the eye due to open-angle glaucoma and ocular hypertension, and protection of eyesight.

Listed below are the typical uses of brinzolamide:

  • To decrease elevated pressure inside the eye due to open-angle glaucoma and ocular hypertension

On occasion your doctor may prescribe this medicine to treat a condition not on the above list. Such conditions are listed below.

  • None known

HOW TO USE/TAKE

How often do I take it?

  • Take brinzolamide exactly as your doctor has told you. The usual dose is one drop in the affected eye or eyes two times a day.
  • Use this medication for the duration of the prescription in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told not to by your doctor.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • Brinzolamide may make you feel sleep or dizzy or have blurred vision. If this happens, do not drive or operate machinery until the effects have gone away. Consult your doctor or pharmacist for more details.

When can I stop?

  • Always complete the full course as prescribed by your doctor.

BRINZOLAMIDE SIDE EFFECTS

  • Blurred vision
  • Eye irritation
  • Eye pain
  • Eye discharge
  • Itchy eye
  • Dry eye
  • Sensation of something in the eye
  • Redness of the eye
  • Eyelid itching, redness or swelling
  • Bad taste in the mouth
  • Headache
  • Dry mouth
  • Abnormal, double or reduced vision
  • Eyelid crusting
  • Watery eyes
  • Sensitivity to light
  • Damage to the optic nerve
  • Decreased eye sensation
  • Growth of the surface of the eye
  • Tired eyes
  • Darkening of the coloured part of the eye
  • Decreased or irregular heart beat
  • Chest pain
  • Asthma, shortness of breath or difficulty breathing
  • Drowsiness
  • Dizziness
  • Reduction in the number of blood cells
  • Memory problems
  • Depression
  • Difficulty sleeping
  • Feeling nervous or irritable
  • Feeling weak
  • Pain
  • Shaking
  • Ringing in the ears
  • Decreased sex drive (libido)
  • Difficulty getting an erection (impotence)
  • Throat irritation
  • Stomach pain
  • Stomach and digestion problems
  • Diarrhoea
  • Kidney pain
  • Muscle pain and spasms
  • Back pain
  • Nose bleeds
  • Dry, stuffy or runny nose
  • Rash
  • Sneezing
  • Loss of hair
  • Abnormal skin sensation

If any of these persist or you consider them severe then inform your doctor or pharmacist.

Tell your doctor immediately if you develop any of the following symptoms:

  • None known

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.

BRINZOLAMIDE PRECAUTIONS

Before taking brinzolamide, tell your doctor or pharmacist if you are allergic to it; or to other carbonic anhydrase inhibitors or sulphonamides; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist in case of:

  • Allergy to brinzolamide or any of the other ingredients, or to sulfonamides
  • Severe kidney problems
  • A condition called hypercholoraemic acidosis that causes your blood to be acidic

Before using this medication tell your doctor or pharmacist your medical history, especially any of the following:

  • Liver problems
  • Dry eyes
  • Problems with the cornea (the transparent surface layer at the front of the eye)
  • Wear contact lenses
  • Pregnancy
  • breastfeeding

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Alcohol is not known to affect this drug.

Wearers of contact lenses. Brinzolamide should be used with caution in people who wear contact lenses as it may affect the moistness of the cornea (the transparent surface layer at the front of the eye), which may then get damaged if contact lenses are worn. In addition, soft contact lenses should be taken out before brinzolamide eye drops are used as they may be discoloured by the preservative in the eye drops. Soft contact lenses can be put back in after waiting 15 minutes.

Diabetes. Brinzolamide should be used with caution in people with diabetes as it may damage the cornea (the transparent surface layer at the front of the eye).

Pregnancy and breastfeeding - please ensure you read the detailed information below

PREGNANCY

The safety of brinzolamide has not been established during pregnancy. The manufacturer therefore states that it should not be taken during pregnancy.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BREAST FEEDING

It is not known whether brinzolamide passes into breast-milk. The manufacturer therefore states that it should not be taken if you are breastfeeding unless clearly necessary.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.

BRINZOLAMIDE INTERACTIONS

Before using this medicine, tell your prescriber of all the medicines you are taking including prescription medicines and medicines you have bought over the counter without a prescription. Tell your prescriber if you are taking vitamins or complementary remedies such as herbal products, as these can also interact with medicines.

If you are taking more than one medicine, these may interact with each other. Your prescriber may decide to use medicines which interact with each other if the benefit outweighs the risks. In these cases, the dose of your medicines may need to be adjusted or you may be monitored more closely.

The following medicines may interact with brinzolamide:

  • Carbonic anhydrase inhibitor medicines, such as acetazolamide and dorzolamide
  • Medicines used for fungal infections, such as ketoconazole, itraconazole, clotrimazole
  • A medicine used to treat HIV infection called ritonavir

This information does not contain all possible interactions. Therefore, tell your prescriber of all the products you are using before taking this medicine.

If you have a question or want to discuss anything about your medicine, speak to your local pharmacist.

BRINZOLAMIDE OVERDOSE

If you use too much brinzolamide eye drops, rinse it out with warm water. If you swallow brinzolamide, you may experience side effects associated with your nervous system and an imbalance of salts in your body. If this occurs, contact your doctor or nearest hospital casualty department as soon as possible.

If you think you, or someone you care for, might have accidentally taken more than the recommended dose of brinzolamide or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.

MISSED DOSE

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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