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Terms Of Use


Brand Name(s) : Chloractil, Largactil
Side Effects


Chlorpromazine should be used with caution in:

It should not be used in:

Also see list of precautions and interactions


Store in a cool and dry place. Store in outer packaging to protect from light


What is it used for?

  • Chlorpromazine is used to treat mental problems by blocking the effects of a chemical in the brain.
  • It is a phenothiazine neuroleptic, sometimes known as phenothiazines.

Listed below are the typical uses of chlorpromazine:

On occasion your doctor may prescribe this medicine to treat a condition not on the above list. Such conditions are listed below:


This medication is available as a tablet and an oral solution to take by mouth, as well as an injection

How often do I take it?

  • Take this medication orally as instructed by your doctor.
  • Chlorpromazine in the injection form will be given to you by your doctor or nurse, usually as an intra-muscular injection. Your doctor may want to carry out some tests, before and during your treatment, to check your heart is working properly.
  • Use this medication for the duration of prescription in order to get the most benefit from it.
  • Remember to use it at the same time each day - unless specifically told otherwise by your doctor.
  • For mood disorders and schizophrenia, it may take up to several weeks before the full benefit of this drug takes effect.
  • Certain medical conditions may require different dosage instructions as directed by your doctor.

What dose?

  • Dosage is based on your age, gender, medical condition, response to therapy, and use of certain interacting medicines.

Do I need to avoid anything?

  • You should not drive or operate machinery if this medication makes you feel drowsy. You should avoid contact with direct sunlight if you are taking high doses of this medicine. Avoid contact with the skin as it may cause dermatitis. If in contact, wash the area thoroughly.
  • Consult your doctor or pharmacist for more details.

When can I stop?

  • Always complete the full course as prescribed by your doctor. Do not stop this medicine without speaking to your doctor first, as stopping it suddenly can result in side effects. If your doctor wants to stop your medication, they will probably decrease your dose gradually, as withdrawal effects may occur if this medicine is stopped suddenly.


  • Inability to sleep
  • nightmares
  • depression
  • agitation
  • dry mouth
  • blocked nose
  • reduced emotion
  • paleness
  • fits
  • hypothermia
  • low blood pressure
  • fast heart beat
  • unusual heart beat
  • jaundice
  • liver problems
  • fever
  • blood disorders
  • inability to sit still
  • change in muscle tone leading to movement difficulties
  • grimacing and tics in the face
  • tremor
  • muscle stiffness
  • skin rash caused by the medicine on the skin
  • skin rashes
  • skin reaction to direct sunlight

Details of other side effects can be found in the package insert.

If any of these persist or you consider them severe then consult your doctor.

Tell your doctor immediately if you develop any of the following symptoms:

  • an allergic reaction. The signs may include: rash, itching, fever, difficulty in breathing or wheezing, chills, swelling, joint aches and pains, swollen joints, feel tired or weak, with chest pain and shortness of breath. These could be signs of an illness called ‘systemic lupus erythematosus’ (SLE).
  • yellowing of the skin or eyes (jaundice)
  • frequent infections such as fever, severe chills, sore throat or mouth ulcers.
  • movements that you cannot control, mainly of the tongue, mouth, jaw, arms and legs.
  • a high temperature, sweating, stiff muscles, fast heartbeat, fast breathing and feeling confused, drowsy or agitated. These could be signs of a serious but rare side effect called ‘neuroleptic malignant syndrome
  • very fast, uneven or forceful heartbeat (palpitations). You may also have breathing problems such as wheezing, shortness of breath, tightness in the chest and chest pain
  • a long lasting, painful erection of the penis
  • bruising more easily than usual

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine (which includes vaccines, herbals and over the counter medicines) that you are taking. It is run by the medicines safety watchdog called the Medicines and Healthcare products Regulatory agency (MHRA). Please report any suspected side effect on the Yellow Card Scheme website.


Before taking chlorpromazine, tell your doctor or pharmacist if you are allergic to it; or to other phenothiazines; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

  • depression of the nervous system (dulled senses),
  • hypothyroidism
  • phaeochromocytoma (tumour of the adrenal gland)
  • severe cardiovascular disease
  • allergy to any of the ingredients

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following:

  • liver disease
  • kidney disease
  • heart problems
  • blood disorders
  • Diabetes
  • History ob blood clots
  • severe respiratory disease or lung disorders,
  • Parkinson's disease
  • narrow angle glaucoma (abnormal pressure in the eye accompanied by pain and blurred vision)
  • enlarged prostate gland
  • epilepsy
  • pregnancy
  • breastfeeding
  • thyroid problems
  • depression
  • alcohol problems or history of alcohol problems
  • muscle weakness with tiredness
  • low levels of potassium, calcium or magnesium in your blood

Before having surgery, tell your doctor or dentist that you are taking this medication.

Does alcohol intake affect this drug?

  • Do not drink alcohol while taking chlorpromazine.

The elderly: elderly patients should take chlorpromazine with caution in very hot or very cold weather.

Pregnancy and breastfeeding - please ensure you read the detailed information below


Chlorpromazine is not safe to take if you are, or are planning to become, pregnant.

It is sensible to limit use of medication during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Chlorpromazine is not safe to take if you are breastfeeding.

It is sensible to limit use of medication during breastfeeding whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

If you have any doubts or concerns you are advised to discuss the medicine with your doctor or pharmacist.


Before using this medicine, tell your prescriber of all the medicines you are taking including prescription medicines and medicines you have bought over the counter without a prescription. Tell your prescriber if you are taking vitamins or complementary remedies such as herbal products, as these can also interact with medicines.

If you are taking more than one medicine, these may interact with each other. Your prescriber may decide to use medicines which interact with each other if the benefit outweighs the risks. In these cases, the dose of your medicines may need to be adjusted or you may be monitored more closely.

The following medicines may interact with chlorpromazine:

  • Amiodarone
  • Droperidol
  • Moxifloxacin
  • Saquinavir
  • Sedatives
  • Anxiety medicines
  • Pain killers (e.g. codeine)
  • Medicines for epilepsy
  • Blood pressure lowering medicine (e.g. guanethidine)
  • Heart medication
  • Astemizole
  • Terfenadine
  • Pimozide
  • Phenylpropanolamine
  • Anti-Parkinson medication e.g. levodopa
  • Medicines for malaria
  • Cimetidine
  • Medicines for diabetes
  • Metirosine
  • Tetrabenazine
  • Lithium
  • Trazodone,
  • Propranolol
  • Sotalol
  • Methyldopa
  • Adrenaline
  • Medicines that control muscle spasms and shaking (anticholinergics)
  • Hypnotics (sleep inducing agents e.g. temazepam)
  • Antacids should be taken at least two hours after taking chlorpromazine

This information does not contain all possible interactions. Therefore, tell your prescriber of all the products you are using before taking this medicine.

If you have a question or want to discuss anything about your medicine, speak to your local pharmacist.


If you think you, or someone you care for, might have accidentally taken more than the recommended dose of chlorpromazine or intentional overdose is suspected, contact your local hospital, GP or if in England call 111. In Scotland call NHS 24. In Wales, call NHS Direct Wales. In the case of medical emergencies, always dial 999.


If you miss a dose, wait until the next dose is due then take a normal. Do not double the dose to catch up.

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Source: Selected from data included with permission and copyrighted by Boots UK Limited. This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.

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